Phase I Study of Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy in Patients With Resectable Esophageal Cancer
Study Status
Closed to Enrollment
Study Description
Currently patients with resectable (can be removed by surgery) esophageal cancer will receive chemotherapy before surgery to try to shrink the tumor before it is removed.
The purpose of this study is to determine whether it is safe to give azacitidine before each cycle of chemotherapy to increase the shrinkage of the tumor prior to surgery.
Azacitidine is currently approved by the Food and Drug Administration (FDA) for treatment of myelodysplastic syndrome (MDS). Azacitidine is not approved by the FDA for use in this study and is therefore considered investigational. Because azacitidine has not been given before in combination with epirubicin, oxaliplatin and capecitabine, we will also evaluate the safety and tolerability of azacitidine and find out what dose of azacitidine is safe to give with this chemotherapy.
Disease Status and/or Stage
Resectable Cancer of the Esophagus or Gastroesophageal Junction (GEJ)
Sponsor
Weill Cornell Medical College
Key Eligibility
- Men and women age 18 to 75
- Cancer of the esophagus or gastroesophageal junction (GEJ) deemed resectable
- No prior chemotherapy for esophageal or GEJ cancer
- Detailed eligibility discussed when you contact the study team
Principal Investigator
Contact
- Gina Mileo, RN
- (212) 746-5430
- [email protected]
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Contact Us
For general inquiries, or if you need assistance finding a study, please contact:
Erica Bersin
Tel: (646) 962-8232
[email protected]