An Open-Labeled, Multicenter Phase II Study of Cabazitaxel in Refractory Metastatic Gastric or Gastroesophageal Adenocarcinoma
Study Status
Open to Enrollment
Study Description
This clinical trial is for men and women with metastatic gastric or gastroesophageal (GEJ) cancer.
The purpose of the study is to determine if the drug cabazitaxel is effective for the treatment of metastatic gastric or GEJ cancer. Cabazitaxel is a chemotherapy medication that helps stop cancer cells from growing and multiplying by interfering with certain structures in the cell. It is FDA-approved for treating prostate cancer but not for gastric cancer.
All participants in this study will receive cabazitaxel; there is no placebo. Study participants will be assigned to one of two study arms:
- Arm A: participants who have never received taxane-based chemotherapy
- Arm B: participants who have previously received taxane-based chemotherapy
Participants in both arms will receive cabazitaxel via infusion once every 3 weeks. The purpose of the arm assignment is to help the researchers analyze if there is a difference in the way different groups respond to the study drug.
Study participants may continue treatment with cabazitaxel as long as they are responding to treatment and do not experience unacceptable side effects.
Disease Status and/or Stage
Metastatic Gastric or Gastroesophageal (GEJ) Cancer
Sponsor
Weill Cornell Medical College
Key Eligibility
- Men and women age 18 and older
- Metastatic gastric or gastroesophageal (GEJ) cancer
- Have had at least 1 prior cytotoxic chemotherapy regimen for metastatic disease; prior taxane therapy is allowed
- Detailed eligibility reviewed when you contact the study team
Principal Investigator
Contact
- Alice Mercado, RN
- (212) 746-5430
- [email protected]
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Contact Us
For general inquiries, or if you need assistance finding a study, please contact:
Erica Bersin
Tel: (646) 962-8232
[email protected]