Utility of Adenosine in Assessing Pulmonary Vein Reconnection After Pulmonary Vein Isolation-Atrial Fibrillation Study

Study Status

Open to Enrollment

Study Description

Catheter ablation has emerged as an effective therapy for patients with atrial fibrillation (AF) in whom medications are not effective. The pulmonary veins (PVs) are the most common source of triggers of AF. Hence, the central approach in catheter ablation of atrial fibrillation involves creating electrical block around the pulmonary veins so that any electrical activity arising from the PVs cannot break out into the heart to initiate atrial fibrillation. 

Catheter ablation involves threading catheters through the groins into the left atrium. Using radiofrequency energy, cautery is performed around the pulmonary veins that drain into the left atrium. The major limiation of this approach is that following ablatiton, electrical isolation of the PVs can be temporary, and reconnection between the PVs and the heart can recur, leading to atrial fibrillation. 

Studies have shown that adenosine (a very short-acting drug used to treat arrhythmias) can be administered following ablation to uncover areas of electrical reconnection. This can be used to guide further ablation that would lead to permanent electrical isolation of the PVs and therefore better long term success rates. 

Our study seeks to understand how adenosine reveals dormant conduction follwing ablation and if adenosine has additive utility when compared to such techniuqes as circumferential PV pacing to assess for exit conduction.

Sponsor

Weill Cornell Medical College Department of Medicine/Division of Cardiology

Key Eligibility

  • All patients undergoing catheter ablation of atrial fibrillation
  • Between the ages of 18 and 85
  • More detailed eligibility discussed when you contact the study team

Principal Investigator

Jim Cheung, MD

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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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