Relationship of Plasma Renin Activity to Response of Microalbuminuria to Angiotensin Converting Enzyme Inhibition

Study Status

Open to Enrollment

Study Description

This is a prospective study to measure levels of the hormone renin and microalbuminuria in patients with mildly elevated microalbuminuria before and after treatment with ACEIs. The presence of small but abnormal levels of the protein albumin in the urine (microalbuminuria) is an early sign of kidney disease, as well as being a predictor of the development of heart disease or stroke. Angiotensin Converting Enzyme-Inhibitors (ACEIs), including Lisinopril, are medicines that are widely used to decrease microalbuminuria. Howwever, there are patients who do not respond to this treatment. If the response could be predicted, only those patients who respond would be given the medicine.The specific objective of this study is to determine if blood renin activity can be used as a predictor of the kidney’s response to Lisinopril.

Eligible subjects will be in this study for 4 weeks and will have the following tests and procedures:

  • At beginning of the study- medical history will be taken, there will be a blood and urine test, and measurement of weight, blood pressure, and heart rate. Subjects will be given supply of the study drug, Lisinopril 10mg daily for 4 weeks.
  • One week after initiation of study- there will be a blood test and blood pressure measurement, and discussion about the response to medication and side effects if any
  • Four weeks after initiation of the study- there will be discussion of the response to medication and side effects if any, and another measurement of weight, blood pressure, and heart rate. A blood test and 2 urine tests will be performed at the end of the study.

All study participants will be reimbursed with $35 upon completion of the study. The study drug Lisinopril will be provided to you free of charge during the study period.

Sponsor

Hypertension Research Fund

Key Eligibility

  • Men and women age 18 and older
  • Have microalbuminuria, not currently receiving ACE-I, ARB or renin inhibitor
  • Have stable medical regimen, aside from the study drug, for the duration of the study
  • Have systolic blood pressure ≥ 100mmHg

Principal Investigator

Mark Pecker, MD

Contact

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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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