Cancer and Blood Disorders
Show Only Open Trials
1.
A Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-221 in Subjects with Advanced Hematologic Malignancies with an IDH2 Mutation
- Study Status: Open to Enrollment
- Sponsor: Agios Pharmaceuticals
- Disease Status and/or Stage: Advanced hematologic malignancies
2.
GO27983: A Phase Ib/II Study of GDC-0068 or GDC-0980 with Abiraterone Acetate versus Abiraterone Acetate in Patients with Castration-Resistant Prostate Cancer Previously Treated with Docetaxel-Based Chemotherapy
- Study Status: Open to Enrollment
- Sponsor: Genentech
- Disease Status and/or Stage: Metastatic or Advanced Prostate Cancer
- Protocol ID: GO27983
3.
A Double-blind, Placebo-controlled Study to Evaluate New or Worsening Lens Opacifications in Subjects with Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss due to Androgen-Deprivation Therapy
- Study Status: Open to Enrollment
- Sponsor: Amgen
- Disease Status and/or Stage: Prostate Cancer Receiving Androgen Deprivation Therapy
4.
A Phase 2, Open-label, Multicenter Study of PSMA ADC in Subjects with Metastatic Castration-resistant Prostate Cancer (mCRPC)
- Study Status: Open to Enrollment
- Sponsor: PSMA Development Company
- Disease Status and/or Stage: Metastatic Castration-Resistant Prostate Cancer
- Protocol ID: PSMA ADC 2301
5.
S1216: Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer
- Study Status: Open to Enrollment
- Sponsor: SWOG
- Disease Status and/or Stage: Metastatic Prostate Cancer
- Protocol ID: S1216
6.
CALGB 30801: A Randomized Phase III Double Blind Trial Evaluating Selective COX-2 Inhibition in COX-2 Expressing Advanced Non-Small Cell Lung Cancer
- Study Status: Closed to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Non Small Cell Lung Cancer (NSCLC)
- Protocol ID: CALGB 30801
7.
Gilead 0125: A Study Evaluating the Efficacy and Safety of Idelalisib(GS-1101) in Combination With Bendamustine and Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas
- Study Status: Open to Enrollment
- Sponsor: Gilead
- Disease Status and/or Stage: Previously Treated Indolent non-Hodgkin Lymphoma
- Protocol ID: Gilead 0125
8.
Gilead 0124: A Study Evaluating the Efficacy and Safety of Idelalisib (GS-1101) in Combination With Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas
- Study Status: Open to Enrollment
- Sponsor: Gilead
- Disease Status and/or Stage: Previously Treated Indolent non-Hodgkin Lymphoma
- Protocol ID: Gilead 0124
9.
A randomized, double-blind, placebo-controlled, phase 3 study of brentuximab vedotin and CHP (A+CHP) versus CHOP in the frontline treatment of patients with CD30-positive mature T-cell lymphomas: the ARROVEN study
- Study Status: Open to Enrollment
- Sponsor: Seattle Genetics
- Disease Status and/or Stage: Untreated Mature T-Cell Lymphoma
10.
A Phase 1a/b Non-Randomized, Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Sterile Compound 31510 (Ubidecarenone, USP) Nanosuspension for Injection Administered Intravenously to Patients with Solid Tumors
- Study Status: Open to Enrollment
- Sponsor: Berg Pharma
- Disease Status and/or Stage: Advanced Solid Tumors
11.
Clinical Performance, Efficacy and Safety of the DigniCap System, a Scalp Hypothermia System, in Preventing Chemotherapy Induced Alopecia in Patients with Early Stage Breast Cancer
- Study Status: Open to Enrollment
- Sponsor: Dignitana AB
- Disease Status and/or Stage: Stage I or II Breast Cancer
- Protocol ID: DIG-001
12.
A Phase 3, Randomized Open Label Trial of Lenalidomide/dexamethasone with or without Elotuzumab in Subjects with Previously Untreated Multiple Myeloma (ELOQUENT - 1)
- Study Status: Open to Enrollment
- Sponsor: Bristol-Myers Squibb
- Protocol ID: BMS CA204006
13.
MLN9708 plus Lenalidomide and Dexamethasone versus Placebo plus Lenalidomide and Dexamethasone in Adult Patients with Newly Diagnosed Multiple Myeloma
- Study Status: Open to Enrollment
- Sponsor: Millennium
- Disease Status and/or Stage: Untreated Multiple Myeloma
- Protocol ID: C16014
14.
Analysis of Hematopoietic Progenitor Cells and Endothelial Progenitor Cells to Predict Early Relapse of Treated Non-Small-Cell Lung Cancer (NSCLC): A Pilot Study
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Non-Small Cell Lung Cancer
15.
A051103: A Phase I Study of Rituximab, Lenalidomide, and Ibrutinib in Previously Untreated Follicular Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Alliance for Clinical Trials in Oncology
- Disease Status and/or Stage: Untreated Follicular Lymphoma
- Protocol ID: A051103
16.
Alliance A051202: A Phase I Trial of Lenalidomide, Rituximab, and Idelalisib in Recurrent Follicular Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Alliance for Clinical Trials in Oncology
- Disease Status and/or Stage: Recurrent Follicular non-Hodgkin Lymphoma
- Protocol ID: A051202
17.
CALGB 100801: Phase II Study of the Addition of Azacitidine to Reduced-Intensity Conditioning Allogeneic Transplantation for Myelodysplasia (MDS) and Older patients With AML
- Study Status: Closed to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Acute Myeloid Leukemia and Myelodysplasia
- Protocol ID: CALGB 100801
18.
Gilead 0119: A Phase 3, Randomized, Controlled Study Evaluating the Efficacy and Safety of GS 1101 (CAL-101) in Combination with Ofatumumab for Previously Treated Chronic Lymphocytic Leukemia
- Study Status: Open to Enrollment
- Sponsor: Gilead
- Disease Status and/or Stage: Previously Treated Chronic Lymphocytic Leukemia (CLL)
- Protocol ID: Gilead 0119
19.
A Phase Ib/IIa Study of Romidepsin in Combination with Lenalidomide in Adults with Relapsed or Refractory Lymphomas and Myeloma
- Study Status: Open to Enrollment
- Sponsor: Memorial Sloan-Kettering Cancer Center
- Disease Status and/or Stage: Relapsed or Refractory Lymphoma and Multiple Myeloma
20.
A Prospective, Longitudinal, Observational Study in Newly Diagnosed Multiple Myeloma (MM) Patients to Assess the Relationship between Patient Outcomes, Treatment Regimens and Molecular Profiles
- Study Status: Open to Enrollment
- Sponsor: Multiple Myeloma Research Foundation
- Disease Status and/or Stage: Untreated Multiple Myeloma
21.
A Phase 3, Randomized Open Label Trial of Lenalidomide/dexamethasone With or Without Elotuzumab in Subjects with Previously Untreated Multiple Myeloma
- Study Status: Open to Enrollment
- Sponsor: Bristol-Myers Squibb
- Disease Status and/or Stage: Untreated Multiple Myeloma
- Protocol ID: BMS - CA204006
22.
An Open-Label Treatment Use Protocol for Ibrutinib (PCI-32765) in Subjects with Relapsed or Refractory Mantle Cell Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Janssen and Pharmacyclics
- Disease Status and/or Stage: Relapsed or Refractory Mantle Cell Lymphoma
- Protocol ID: PCI-32765MCL4001
23.
24.
A Phase III Study of Onartuzumab (MetMAb) in Combination With mFOLFOX6 in Patients With Metastatic HER2-Negative And Met-Positive Gastroesophageal Cancer (MetGastric)
- Study Status: Open to Enrollment
- Sponsor: Genentech
- Disease Status and/or Stage: Metastatic Gastric Cancer
- Protocol ID: YO28322
25.
LUX-Lung 8: A randomized, open-label Phase III trial of afatinib versus erlotinib in patients with advanced squamous cell carcinoma of the lung as second-line therapy following first-line platinum-based chemotherapy
- Study Status: Closed to Enrollment
- Sponsor: Boehringer Ingelheim Pharmaceuticals
- Disease Status and/or Stage: Previously Treated Advanced Squamous Cell Lung Cancer
26.
Tocilizumab (an anti-human IL-6 receptor monoclonal antibody) as a first line therapy for patients with glucocorticoid-refractory acute graft vs. host disease (aGVHD) after allogeneic hematopoietic stem cell transplant (HSCT), a Phase II study
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Steroid-Refractory Acute Graft-versus-Host Disease (GVHD)
27.
A Randomized Controlled Study of Extracorporeal Photopheresis (ECP) Therapy with UVADEX™ for the Treatment of Patients with Moderate to Severe Chronic Graft versus Host Disease (cGVHD)
- Study Status: Open to Enrollment
- Sponsor: Therakos
- Disease Status and/or Stage: Moderate to Severe Graft-versus-Host Disease (GVHD)
28.
RDCRN 6503: Targeted Therapy of Bronchiolitis Obliterans Syndrome
- Study Status: Open to Enrollment
- Sponsor: NIH, GVHD Consortium
- Disease Status and/or Stage: Bronchiolitis Obliterans Syndrome (BOS) after Hematopoietic Cell Transplant (HCT)
29.
RDCRN 6502: A Randomized Phase II Study of Imatinib and Rituximab for Cutaneous Sclerosis after Allogeneic Hematopoietic Cell Transplantation
- Study Status: Open to Enrollment
- Sponsor: NIH, GVHD Consortium
- Disease Status and/or Stage: Cutaneous Sclerosis after Hematopoietic Cell Transplant (HCT); blood disorders; rituximab; imatinib; Sebastian Mayer MD; Weill Cornell Bone Marrow Transplant; stem cell transplant; New York Presbyterian Hospital
- Protocol ID: RDCRN 6502
30.
Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD)
- Study Status: Open to Enrollment
- Sponsor: Fresenius Biotech GmbH
- Disease Status and/or Stage: Acute Lymphocytic Leukemia (ALL), Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
- Protocol ID: IV-ATG-SCT-01
31.
A Randomized, Open-Label, Phase 3 Study of BMS-936558 vs Everolimus in Subjects with Advanced or Metastatic Clear-Cell Renal Cell Carcinoma Who Have Received Prior Anti-Angiogenic Therapy
- Study Status: Open to Enrollment
- Sponsor: Bristol-Myers Squibb
- Disease Status and/or Stage: Advanced or Metastatic Kidney Cancer
- Protocol ID: BMS CA209-025-041
32.
A Phase 1 Dose Escalation Study of OMP-52M51 in Subjects with Lymphoid Malignancies
- Study Status: Open to Enrollment
- Sponsor: OncoMed
- Disease Status and/or Stage: Relapsed or Refractory Lymphoid Malignancies, Including Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL), Diffuse Large B-cell Lymphoma (DLBCL), Transformed Mycosis Fungoides (MF), or Sezary Syndrome
- Protocol ID: 52M51-001
33.
An Open-label, Multicenter, Single-arm, Phase 2 Study of PCI-32765 (Ibrutinib) in Subjects with Refractory Follicular Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Janssen
- Disease Status and/or Stage: Refractory Follicular Lymphoma
- Protocol ID: PCI-32765FLR2002
34.
A Phase 3, Randomized, Double-blind, Controlled Study of Cabozantinib (XL184) vs. Prednisone in Metastatic Castration-resistant Prostate Cancer Patients who have Received Prior Docetaxel and Prior Abiraterone or MDV3100
- Study Status: Open to Enrollment
- Sponsor: Exelixis
- Disease Status and/or Stage: Metastatic Castration-Resistant Prostate Cancer
- Protocol ID: XL184-307
35.
S1117: A Randomized Phase II Study of Azacitidine in Combination with Lenalidomide vs. Azacitidine Alone vs. Azacitidine in Combination with Vorinostat for Higher-Risk Myelodysplatic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)
- Study Status: Closed to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Higher Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)
- Protocol ID: S1117
36.
A phase II study of brentuximab vedotin as salvage therapy for Hodgkin Lymphoma prior to autologous hematopoietic stem cell transplantation
- Study Status: Open to Enrollment
- Sponsor: City of Hope
- Disease Status and/or Stage: Relapsed or Refractory to One Frontline Induction Therapy
37.
Phase III, Multicenter, Randomized, Trial of CPX-351 (cytarabine: daunorubicin) liposome injection versus cytarabine and daunorubicin in patients 60-75 years of age with untreated high risk (secondary) AML (protocol CLTR0310-301)
- Study Status: Open to Enrollment
- Sponsor: Celator
- Disease Status and/or Stage: Newly Diagnosed High Risk AML, Age 60 to 75
38.
A Phase 2, Randomized, Open-Label Study of the Safety and Efficacy of Two Doses of Quizartinib (AC220; ASP2689) in Subjects with FLT3-ITD Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
- Study Status: Closed to Enrollment
- Sponsor: Astellas Pharma
- Disease Status and/or Stage: Relapsed or Refractory Acute Myeloid Leukemia (AML); AC220; ASP2689; blood cancer treatment; Ellen Ritchie; Gail Roboz; Weill Cornell Leukemia: New York Presbyterian Hospital
39.
Phase II Study of SAR302503 in Subjects Previously Treated with Ruxolitinib and with a diagnosis of Intermediate-2 or High-Risk PM, Post-PV Myelofibrosis, or Post-ET Myelofibrosis
- Study Status: Closed to Enrollment
- Sponsor: Sanofi Aventis
40.
Phase 3 randomized study to evaluate the substitution of Marqibo for standard vincristine sulfate injection in combination chemotherapy for subjects ≥ 60 yrs old w/ newly diagnosed ALL
- Study Status: Open to Enrollment
- Sponsor: Talon Therapeutics
- Disease Status and/or Stage: Newly Diagnosed ALL, Age 60 and Older
41.
42.
A Phase Ib Rising Multiple-Dose Clinical Study to Evaluate Safety, Tolerability, and Activity of Oral Monotherapy with KX2-391 in Elderly Subjects with Acute Myeloid Leukemia (AML) Who Are Refractory to or Have Declined Standard Induction Therapy
- Study Status: Closed to Enrollment
- Sponsor: Kinex
- Disease Status and/or Stage: Acute Myeloid Leukemia (AML) in Subjects Age 60 and Older
43.
A Phase 2 Study of LY2784544 in Patients with Myeloproliferative Neoplasms
- Study Status: Open to Enrollment
- Sponsor: Ely Lilly
- Disease Status and/or Stage: Polycythemia Vera (PV), Essential Thrombocythemia (ET), or Myelofibrosis (MF)
44.
Phase II randomized controlled trial of pegylated interferon alpha-2b in early primary myelofibrosis
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Low or Intermediate Stage Primary Myelofibrosis (PMF)
45.
Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission Therapy
- Study Status: Closed to Enrollment
- Sponsor: Memorial Sloan-Kettering Cancer Center
- Disease Status and/or Stage: Newly Diagnosed Acute Promyelocytic Leukemia
46.
A Phase II Trial of the Aurora Kinase A Inhibitor MLN8237 in Patients with Metastatic Castrate Resistant and Neuroendocrine Prostate Cancer
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
47.
An Open-label, Randomized Phase 3 Study of Inotuzumab Ozogamicin Compared to a Defined Investigator's Choice in Adult Patients with Relapsed or Refractory CD22-Positive Acute Lymphoblastic Leukemia
- Study Status: Open to Enrollment
- Sponsor: Pfizer
- Disease Status and/or Stage: Relapsed/Refractory Acute Lymphoblastic Leukemia
48.
A Phase 3 Randomized, Open-Label Study of Ponatinib versus Imatinib in Adult Patients with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase
- Study Status: Closed to Enrollment
- Sponsor: Ariad
- Disease Status and/or Stage: Newly Diagnosed Chronic Myeloid Leukemia
- Protocol ID: AP24534-12-301
49.
An Open Label Multicenter Phase 2 Window of Opportunity Study Evaluating Ganetespib (STA-9090) Monotherapy in Women with Previously Untreated Metastatic HER2 Positive or Triple Negative Breast Cancer
- Study Status: Open to Enrollment
- Sponsor: Synta
- Disease Status and/or Stage: Previously Untreated Metastatic HER2-Positive or Triple Negative Breast Cancer
50.
A Double-blind, Randomized Phase II Trial of Active Immunotherapy with Globo H-KLH (OPT-822) in Subjects with Metastatic Breast Cancer
- Study Status: Open to Enrollment
- Sponsor: Optimer Biotechnology
- Disease Status and/or Stage: Metastatic Breast Cancer
51.
A Phase I/II Trial of Temsirolimus Plus Neratinib for Subjects with Metastatic HER2-Amplified or Triple Negative Breast Cancer
- Study Status: Open to Enrollment
- Sponsor: Puma
- Disease Status and/or Stage: HER2-Positive Metastatic Breast Cancer
52.
Phase I Study of IMMU-132 (hRS7-SN38 Antibody Drug Conjugate) in Patients with Epithelial Cancer
- Study Status: Open to Enrollment
- Sponsor: Immunomedics
- Disease Status and/or Stage: Metastatic Epithelial Cancer
53.
A Phase II Study of Daily Alternating Thalidomide and Lenalidomide Therapy Plus Rituximab (THRiL) as Initial Treatment for Patients with CLL
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Untreated CLL
54.
A Multi-center, Randomized, Phase 3 Study of Sequential Pralatrexate Versus Observation in Patients with Previously Undiagnosed Peripheral T-cell Lymphoma Who Have Achieved an Objective Response Following Initial Treatment with CHOP-based Chemotherapy
- Study Status: Open to Enrollment
- Sponsor: Allos Therapeutics
- Disease Status and/or Stage: Peripheral T-Cell Lymphoma
- Protocol ID: PDX-017
55.
A Study of Trastuzumab Emtansine Versus Taxane in Patients With Advanced Gastric Cancer
- Study Status: Open to Enrollment
- Sponsor: Hoffmann-La Roche/Genentech
- Disease Status and/or Stage: Advanced or Metastatic HER2-Positive Gastric or GEJ Cancer
- Protocol ID: BO27952
56.
A Prospective Randomized Trial Comparing Three Different Peripheral Stem Cell Mobilization Regimens in Patients With Symptomatic Multiple Myeloma
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Mutliple Myeloma
57.
The BEACON Study (Breast Cancer Outcomes With NKTR-102)
- Study Status: Open to Enrollment
- Sponsor: Nektar Therapeutics
- Disease Status and/or Stage: Locally Recurrent or Metastatic Breast Cancer Previously Treated with Cytotoxic Chemotherapy
58.
A multicenter safety study of unlicensed, investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients
- Study Status: Open to Enrollment
- Sponsor: National Cord Blood Program
- Disease Status and/or Stage: Hematologic Malignancies and Other Indications Receiving Allogeneic Hematopoieic Stem Cell Transplant
59.
A Multicenter Phase 1-2 Study of MLN8237, an Oral Aurora A Kinase Inhibitor, in Patients with Relapsed or Refractory Aggressive B-Cell Lymphoma Treated with Rituximab and Vincristine
- Study Status: Open to Enrollment
- Sponsor: Millennium
- Disease Status and/or Stage: Relapsed/Refractory Diffuse Large B-Cell Lymphoma, Transformed Follicular Lymphoma, Mantle Cell Lymphoma or Burkitt Lymphoma
- Protocol ID: C14011
60.
Fludeoxyglucose F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer
- Study Status: Open to Enrollment
- Sponsor: NCI
- Disease Status and/or Stage: Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer
61.
A phase III trial of adjuvant chemotherapy following chemoradiation as primary treatment for locally advanced cervical cancer compared to chemoradiation alone: THE OUTBACK TRIAL
- Study Status: Open to Enrollment
- Sponsor: Gynecologic Oncology Group; National Cancer Institute
- Disease Status and/or Stage: Locally Advanced Cervical Cancer
62.
Phase II Trial of Combination Pemetrexed (Alimta) and Carboplatin (Paraplatin) in Platinum Sensitive Recurrent Ovarian, Primary Peritoneal, and Fallopian Tube Carcinoma
- Study Status: Open to Enrollment
- Sponsor: Montefiore Medical Center
- Disease Status and/or Stage: Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancer
63.
A Phase Ib Study of Fractionated 90Y-hPAM4 with or without Gemcitabine in Patients with Metastatic Pancreatic Cancer who Received at Least Two Prior Treatments
- Study Status: Closed to Enrollment
- Sponsor: Immunomedics
- Disease Status and/or Stage: Stage IV Metastatic Pancreatic Cancer
- Protocol ID: IM-T-hPAM4-03
64.
Lenalidomide plus Melphalan as a Preparative Regimen for Autologous Stem Cell Transplantation in Relapsed Multiple Myeloma: A Phase 1 / 2 Study
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Relapsed/Refractory Multiple Myeloma
65.
ENDEAVOR: A Randomized, Open-label, Phase 3 Study of Carfilzomib Plus Dexamethasone Versus Bortezomib Plus Dexamethasone in Patients With Relapsed Multiple Myeloma
- Study Status: Open to Enrollment
- Sponsor: Onyx Pharmaceuticals
- Disease Status and/or Stage: Relapsed Multiple Myeloma
- Protocol ID: 2011-003 ENDEAVOR
66.
An Open-Labeled, Multicenter Phase II Study of Cabazitaxel in Refractory Metastatic Gastric or Gastroesophageal Adenocarcinoma
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Metastatic Gastric or Gastroesophageal (GEJ) Cancer
67.
A Phase II Study of Dexamethasone (Decadron), Clarithromycin (Biaxin), and Pomalidomide (CC-4047) for Subjects with Relapsed or Refractory Multiple Myeloma
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Relapsed or Refractory Multiple Myeloma
68.
N093B: Phase I/II Study of Panobinostat (LBH589) and Letrozole in Patients with Triple Negative Metastatic Breast Cancer
- Study Status: Open to Enrollment
- Sponsor: Cancer Trials Support Unit (CTSU)
- Disease Status and/or Stage: Triple Negative Metastatic Breast Cancer
- Protocol ID: N093B
69.
PRESENT: Prevention of Recurrence in Early-Stage, Node-Positive Breast Cancer with Low to Intermediate HER2 Expression with NeuVaxâ„¢ Treatment
- Study Status: Open to Enrollment
- Sponsor: Galena Biopharma
- Disease Status and/or Stage: HER2 1+/2+, Node Positive Breast Cancer
70.
A Phase 3, Randomized, Two-Arm, Open-Label, Multicenter, International Trial of Alisertib (MLN8237) or Investigator's Choice (Selected Single Agent) in Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Millennium
- Disease Status and/or Stage: Relapsed/Refractory Peripheral T-Cell Lymphoma
- Protocol ID: C14012
71.
A Phase II Study of Sequential Carfilzomib, Clarithromycin, Lenalidomide, and Dexamethasone (Car-BiRD) Therapy for Subjects with Newly Diagnosed Multiple Myeloma
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Newly Diagnosed Multiple Myeloma; No Previous Treatment
72.
BMS CA204007: A Phase 1b Study of Elotuzumab in Combination with Lenalidomide and Dexamethasone in Subjects with Multiple Myeloma and Normal Renal Function, Severe Renal Impairment, or End Stage Renal Disease Requiring Dialysis
- Study Status: Open to Enrollment
- Sponsor: Bristol-Myers Squibb
- Disease Status and/or Stage: Multiple Multiple and Normal Renal Function, Severe Renal Impairment, or on Dialysis
- Protocol ID: BMS CA204007
73.
An Open-label Phase 2 Study of ACE-041 in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
- Study Status: Closed to Enrollment
- Sponsor: Acceleron
- Disease Status and/or Stage: Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck
74.
A Randomized study of Combined Haplo-identical Umbilical Cord Transplantation vs. Double Umbilical Cord Transplantation in Patients with Hematologic Malignancies
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Hematologic Malignancies in Need of Donor Stem Cell Transplant
75.
A Study of Trastuzumab in Combination With Cisplatin/Capecitabine Chemotherapy in Patients With HER2-Positive Metastatic Gastric or Gastro-Esophageal Junction Cancer
- Study Status: Open to Enrollment
- Sponsor: Genentech/Roche
- Disease Status and/or Stage: Metastatic Gastric Cancer
76.
BMT CTN 0903 - Allogeneic Hematopoietic Cell Transplant for Hematological Cancers and Myelodysplastic Syndromes in HIV-Infected Individuals
- Study Status: Open to Enrollment
- Sponsor: BMT-CTN
- Disease Status and/or Stage: Hematologic Cancers and Myelosysplastic Syndromes in HIV-Positive People
- Protocol ID: BMT CTN 0903
77.
CALGB 80702: A Phase III Trial of 6 versus 12 Treatments of Adjuvant Folfox Plus Celecoxib or Placebo for Patients with Resected Stage III Colon Cancer
- Study Status: Open to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Resected Stage III Colon Cancer
- Protocol ID: CALGB 80702
78.
CALGB 50801: Phase II Trial of Response-Adapted Therapy Based on Positron Emission of Tomography (PET) for Bulky Stage I and Stage II Classical Hodgkin Lymphoma (HL)
- Study Status: Open to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Bulky, Early Stage Hodgkin Lymphoma
79.
CALGB 50604: Phase II Trial of Response-Adapted Chemotherapy Based on Positron Emission Tomography for Non-Bulky Stage I and II Hodgkin Lymphoma
- Study Status: Closed to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Hodgkin Lymphoma, Stage IA, IB, IIA or IIB
- Protocol ID: CALGB 50604
80.
A randomized, double-blind, placebo-controlled phase III study to evaluate the efficacy and safety of pazopanib as adjuvant therapy for subjects with localized or locally advanced RCC following nephrectomy
- Study Status: Open to Enrollment
- Sponsor: GlaxoSmithKline
- Disease Status and/or Stage: Kidney Cancer, Surgically Removed
81.
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Idelalisib (GS-1101) in Combination with Rituximab for Patients with Previously Treated Chronic Lymphocytic Leukemia
- Study Status: Open to Enrollment
- Sponsor: Gilead Sciences, Inc.
- Disease Status and/or Stage: Previously Treated Chronic Lymphocytic Leukemia (CLL)
- Protocol ID: 0116
82.
Single Arm Salvage Therapy With Pegylated Interferon Alfa-2a for Patients With High Risk Polycythemia Vera or High Risk Essential Thrombocythemia Who Are Either Hydroxyurea Resistant or Intolerant or Have Had Abdominal Vein Thrombosis
- Study Status: Open to Enrollment
- Sponsor: Myeloproliferative Disorders-Research Consortium
- Disease Status and/or Stage: High Risk Polycythemia Vera; High Risk Essential Thrombocythemia
- Protocol ID: MPD-RC 111
83.
Randomized, Open Label, Multicenter Phase III Study of Efficacy and Safety in Polycythemia Vera Subjects Who Are Resistant to or Intolerant of Hydroxyurea: JAK Inhibitor INC424 Tablets Versus Best Available Care (The RESPONSE Trial)
- Study Status: Closed to Enrollment
- Sponsor: Incyte Corporation
- Disease Status and/or Stage: Polycythemia Vera (PV)
84.
Ruxolitinib (INCB018424) in Subjects With Primary Myelofibrosis, Post Essential Thrombocythemia-myelofibrosis and Post Polycythemia Vera-myelofibrosis
- Study Status: Closed to Enrollment
- Sponsor: Incyte Corporation
- Disease Status and/or Stage: Primary Myelofibrosis; Post Essential Thrombocythemia-myelofibrosis; Post Polycythemia Vera-myelofibrosis
85.
A Phase 1/2 Safety and Efficacy Study of Orally Administered PLX3397 in Adults With Relapsed or Refractory Flt3-ITD positive Acute Myeloid Leukemia
- Study Status: Open to Enrollment
- Sponsor: Plexxikon
86.
CALGB 50901: A Phase II Trial of Ofatumumab (CALGB IND #112390) in Previously Untreated Follicular Non-Hodgkin's Lymphoma (NHL)
- Study Status: Open to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Untreated Follicular Lymphoma
- Protocol ID: CALGB 50901
87.
CALGB 70807: The Men's Eating and Living (MEAL) Study: A Randomized Trial of Diet to Alter Disease Progression in Prostate Cancer Patients on Active Surveillance
- Study Status: Open to Enrollment
- Sponsor: CALGB
88.
S1108: A Phase II Trial of the Aurora Kinase A Inhibitor MLN8237, in Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma
- Study Status: Open to Enrollment
- Sponsor: SWOG
- Disease Status and/or Stage: Relapsed/Refractory Peripheral T-Cell non-Hodgkin Lymphoma
89.
Phase I/II Study of Veltuzumab Combined with 90Y-Epratuzumab Tetraxetan in Patients with Relapsed/Refractory, Aggressive Non-Hodgkin's Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Immunomedics
90.
CALGB 50904: A Randomized Phase II Trial of Ofatumumab and Bendamustine vs. Ofatumumab, Bortezomib (NSC #681239, IND #58443) and Bendamustine in Patients with Untreated Follicular Lymphoma
- Study Status: Open to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Untreated Follicular Lymphoma
- Protocol ID: CALGB 50904
91.
A Multicenter, Open-label, Phase 2, Safety and Efficacy Study of the Bruton's Tyrosine Kinase (Btk) Inhibitor, PCI-32765, in Subjects with Relapsed or Refractory De Novo diffuse Large B-Cell Lymphoma (PCYC 1106)
- Study Status: Open to Enrollment
- Sponsor: Pharmacyclics
- Disease Status and/or Stage: Relapsed or Refractory de Novo Diffuse Large B-cell Lymphoma (DLBCL)
92.
Clinical Database and Tissue Repository Collection Project for the Study of Waldenstrom's Macroglobulinemia
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
93.
E1505: A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (> 4 cm) -IIIA Non-Small Cell Lung Cancer (NSCLC)
- Study Status: Open to Enrollment
- Sponsor: Eastern Cooperative Oncology Group
94.
REO 022: A Multicenter Phase 1 Study of Intravenous Administration of REOLYSIN® (Reovirus Type 3 Dearing) in Combination with Irinotecan/Fluorouracil/Leucovorin (FOLFIRI) in Patients with Oxaliplatin Refractory/Intolerant KRAS Mutant Colorectal Cancer
- Study Status: Closed to Enrollment
- Sponsor: Oncolytics Biotech, Inc.
- Disease Status and/or Stage: Colon Cancer
95.
CALGB 11002 - A Randomized Phase II Trial of Decitabine-Based Induction Strategies for Patients ≥ 60 Years Old With Acute Myeloid Leukemia (AML)
- Study Status: Closed to Enrollment
- Sponsor: CALGB
- Disease Status and/or Stage: Acute Myeloid Leukemia
96.
REO 017: A Phase 2 Study of Reolysin® in Combination with Gemcitabine for Patients with Advanced Pancreatic Adenocarcinoma
- Study Status: Closed to Enrollment
- Disease Status and/or Stage: Advanced or Metastatic Pancreatic Cancer
97.
A Phase II Study of Tetrathiomolybdate (TM) in patients with breast cancer at moderate to high risk of recurrence
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: High-Risk Stage II Breast Cancer; Stage III Breast Cancer; Stage IV Breast Cancer in Remission
98.
Prospective Data Collection Among Women Using Cold Caps During TC Chemotherapy
- Study Status: Open to Enrollment
- Disease Status and/or Stage: Early-Stage Breast Cancer
99.
A Randomized, Double-Blind, Phase 3 Study of Docetaxel and Ramucirumab versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small Cell Lung Cancer Following Disease Progression after One Prior Platinum-Based Therapy
- Study Status: Open to Enrollment
- Sponsor: Lilly
- Disease Status and/or Stage: Stage IV Non-Small Cell Lung Cancer
100.
A Phase 1b Safety Study of Abiraterone Acetate (JNJ 212082) and Docetaxel in Subjects with Metastatic Castration-Resistant Prostate Cancer (mCRPC) (COU-AA-206)
- Study Status: Open to Enrollment
- Sponsor: Cougar Biotechnology
- Disease Status and/or Stage: Metastatic Castration-Resistant Prostate Cancer
101.
Phase II Study of Lenalidomide plus Rituximab in Patients with Previously Untreated Mantle Cell Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Untreated Mantle Cell Lymphoma
102.
Phase I Study of Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy in Patients With Resectable Esophageal Cancer
- Study Status: Closed to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Resectable Cancer of the Esophagus or Gastroesophageal Junction (GEJ)
103.
A random assignment phase II study of modified docetaxel, cisplatin, and fluorouracil (mDCF) versus parent DCF with growth factor support in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma
- Study Status: Open to Enrollment
- Disease Status and/or Stage: Metastatic or Unresectable Gastric or Gastroesophageal Junction (GEJ) Cancer
104.
An Open-Label, Randomized, Phase 2 Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma Patients
- Study Status: Open to Enrollment
- Sponsor: Millennium Pharmaceuticals
- Disease Status and/or Stage: Previously untreated Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma
105.
Phase 1 Study of PD 0332991 Plus Bortezomib in Patients with Previously Treated Mantle Cell Lymphoma
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Mantle Cell Lymphoma (MCL)
106.
Treatment Decision Making in Elderly Patients with Hematological Malignancies: New Approaches to an Old Problem
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Hematological Malignancies
107.
A Phase 3, Randomized, Controlled, Double-Blind, Multinational Clinical Study of the Efficacy and Safety of Vosaroxin and Cytarabine Versus Placebo and Cytarabine in Patients With First Relapsed or Refractory Acute Myeloid Leukemia (VALOR)
- Study Status: Closed to Enrollment
- Sponsor: Sunesis Pharmaceuticals
- Disease Status and/or Stage: Acute Myeloid Leukemia or Acute Nonlymphocytic Leukemia
108.
Phase III MultiCenter Randomized Controlled Study to Assess Efficacy and Safety of ON 01910.Na 72-Hr Continuous IV Infusion in MDS Patients With Excess Blasts Relapsing After or Refractory to or Intolerant to Azacitidine or Decitabine
- Study Status: Closed to Enrollment
- Sponsor: Onconova Therapeutics, Inc
- Disease Status and/or Stage: Myelodysplastic Syndromes (MDS) Including RAEB and Chronic Myelomonocytic Leukemia (CMML)
109.
CALGB 10403: An Intergroup Phase II Clinical Trial for Adolescents and Young Adults With Untreated Acute Lymphoblastic Leukemia (ALL)
- Study Status: Closed to Enrollment
- Sponsor: CALGB; NCI; Eastern Cooperative Oncology Group; Southwest Oncology Group
- Disease Status and/or Stage: Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
- Protocol ID: CALGB 10403
110.
A Phase 1, Dose Escalation, Multicenter Study of Two Subcutaneous Regimens of SGI-110, a DNA Hypomethylating Agent, in Subjects With Intermediate-2 or High-Risk Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)
- Study Status: Open to Enrollment
- Sponsor: SuperGen
- Disease Status and/or Stage: Intermediate-2 or high-risk Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)
111.
Pilot study of abbreviated chemotherapy based on early positron emission tomography in Hodgkin lymphoma
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Untreated Hodgkin Lymphoma
112.
MPD-RC 108: Phase II, Randomized, Double-Blind, Placebo Controlled International Study of Clopidogrel and Aspirin for the Treatment of Polycythemia Vera
- Study Status: Closed to Enrollment
- Sponsor: Myeloproliferative Disorders-Research Consortium
- Disease Status and/or Stage: Polycythemia Vera (PV)
113.
A Randomized, Double Blind, Placebo Controlled Study Evaluating the Efficacy and Safety of Romiplostim Treatment of Thrombocytopenia in Subjects with Low or Imtermediate-1 Risk Myelodysplastic Syndrome (MDS)
- Study Status: Closed to Enrollment
- Disease Status and/or Stage: Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
114.
A Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate Radical Prostatectomy in Patients with High-Risk, Clinically Localized Prostate Cancer
- Study Status: Open to Enrollment
- Sponsor: Cancer and Leukemia Group B, National Cancer Institute
- Disease Status and/or Stage: High Risk, Clinically Localized Prostate Cancer
- Protocol ID: CALGB 90203
115.
Radioimmunotherapy Phase I Dose-Escalation Studies in Prostate Cancer using 177Lu-J591 Antibody: Dose Fractionation Regimen
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Metastatic Prostate Cancer
116.
A Randomized Phase 2 Trial of 177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and ketoconazole in Patients with High-Risk Castrate Biochemically Relapsed Prostate Cancer After Local Therapy
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Relapsed Prostate Cancer
117.
A Phase I Trial of Docetaxel/Prednisone plus Fractionated 177Lu-J591 Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody in Patients with Metastatic, Castrate-Resistant Prostate Cancer
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Metastatic Prostate Cancer
118.
A Phase III trial of short term androgen deprivation with pelvic lymph node or prostate bed only radiotherapy (SPPORT) in prostate cancer patients with a rising PSA after radical prostatectomy
- Study Status: Open to Enrollment
- Sponsor: Radiation Therapy Oncology Group, National Cancer Institute
- Disease Status and/or Stage: Prostate Cancer After Radical Prostatectomy
119.
A Phase 1B, Open-Label, Dose Escalation Study Evaluating the Safety of BSI-201 in Combination with Chemotherapeutic Regimens in Subjects with Advanced Solid Tumors
- Study Status: Closed to Enrollment
- Sponsor: BiPar Sciences
- Disease Status and/or Stage: Metastatic Pancreatic Cancer
120.
A Randomized, Double-Blind, Placebo-Controlled Multicenter Phase 2 Study of the Efficacy and Safety of Apricoxib in Combination with either Docetaxel or Pemetrexed in Non-Small Cell Lung Cancer Patients
- Study Status: Open to Enrollment
- Sponsor: Tragara Pharmaceuticals
- Disease Status and/or Stage: Stage IIIB/IV or Recurrent, Unresectable Non-Small Cell Lung Cancer
121.
Chemotherapy and Radiation in Treating Patients With Stage 3 Non-Small Cell Lung Cancer (PROCLAIM)
- Study Status: Open to Enrollment
- Sponsor: Eli Lily & Co.
- Disease Status and/or Stage: Unresectable, Locally Advance, Stage III Non-Small Cell Lung Cancer
122.
CALGB 140503: A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (<2cm) Peripheral Non-Small Cell Lung Cancer
- Study Status: Open to Enrollment
- Sponsor: Cancer and Leukemia Group B, National Cancer Institute
- Disease Status and/or Stage: Non-small Cell Lung Cancer
123.
A Phase I/II Study of Vorinostat in Combination with Isotretinoin in the Treatment of Patients with Advanced Renal Cell Carcinoma
- Study Status: Closed to Enrollment
- Sponsor: Weill Cornell Medical College, National Cancer Institute
- Disease Status and/or Stage: Metastatic or Advanced Kidney Cancer
124.
A Phase I/II Trial of BAY 43-9006 plus Gemcitabine and Capecitabine in the Treatment of Patients with Advanced Renal Cell Carcinoma
- Study Status: Closed to Enrollment
- Sponsor: Weill Cornell Medical College, National Cancer Institute
- Disease Status and/or Stage: Advanced, Unresectable and/or Metastatic Kidney Cancer
125.
ECOG 2805: A Randomized, Double-Blind Phase III Trial of Adjuvant Sunitinib versus Sorafenib versus Placebo in Patients with Resected Renal Cell Carcinoma (RCC)
- Study Status: Closed to Enrollment
- Sponsor: Eastern Cooperative Oncology Group
- Disease Status and/or Stage: Renal Cell Cancer
126.
A Phase II Trial of Temsirolimus and Bevacizumab in Patients With Endometrial, Ovarian, Hepatocellular Carcinoma, Carcinoid and Islet Cell Cancer
- Study Status: Closed to Enrollment
- Sponsor: Mayo Clinic, National Cancer Institute
- Disease Status and/or Stage: Locally Advanced, Recurrant or Metastatic disease
127.
A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, and Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients With Advanced Transitional Cell Carcinoma
- Study Status: Open to Enrollment
- Sponsor: Cancer and Leukemia Group B (CALGB); National Cancer Institute (NCI)
- Disease Status and/or Stage: Advanced Transitional Cell Carcinoma
128.
A Phase I Study of 177Lu Radiolabeled Monoclonal Antibody HuJ591-GS (177Lu-591) in Patients with Nonprostate Metastatic Solid Tumors: A Pilot Study
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College
- Disease Status and/or Stage: Metastatic Solid Tumor
129.
A Phase II, Multicenter, Randomized, Open-Label Study Comparing Eribulin Mesylate and Ixabepilone in Causing or Exacerbating Neuropathy in Patients with Advanced Breast Cancer
- Study Status: Open to Enrollment
- Sponsor: Eisai
- Disease Status and/or Stage: Advanced Breast Cancer and Neuropathy
130.
Phase II study of ixabepilone in patients with metastatic breast cancer and a prospective evaluation of its effects on the ultrastructure of neurons
- Study Status: Open to Enrollment
- Sponsor: Weill Cornell Medical College; Bristol-Myers Squibb
- Disease Status and/or Stage: Metastatic Breast Cancer
131.
ACOSOG Z1072: A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma
- Study Status: Open to Enrollment
- Sponsor: American College of Surgeons/National Cancer Institute
- Disease Status and/or Stage: Invasive Breast Cancer
132.
A Randomized Placebo-Controlled Trial of Glutamine to Reduce the Signs and Symptoms of Peripheral Neuropathy in Breast Cancer Patients with a Mild Peripheral Neuropathy Receiving Paclitaxel Chemotherapy
- Study Status: Open to Enrollment
- Disease Status and/or Stage: Breast Cancer, any stage
133.
A Phase II Study of Tetrathiomolydate (TM) in patients with breast cancer at moderate to high risk for recurrence
- Study Status: Open to Enrollment
- Disease Status and/or Stage: Breast Cancer at moderate to high risk of recurrence (based on the number of lymph nodes); Stage 4 breast cancer without any evidence of disease
