A Phase III trial of short term androgen deprivation with pelvic lymph node or prostate bed only radiotherapy (SPPORT) in prostate cancer patients with a rising PSA after radical prostatectomy

Study Status

Open to Enrollment

Study Description

Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells. Antihormone therapy may lessen the amount of androgens made by the body. It is not yet known which regimen of radiation therapy with or without androgen deprivation therapy is more effective for prostate cancer.

This clinical trial is studying prostate radiation therapy to see how well it works compared with short-term androgen deprivation therapy given together with pelvic lymph node radiation therapy with or without proostate radiation therapy with or without prostate radiation therapy in treating patients with a rising PSA after surgery for prostate cancer.

There are 3 arms in this study:

  • Arm 1 Prostate bed radiotherapy (PBRT) alone: patients undergo PBRT once daily, 5 days a week for approximately 7-8 weeks
  • Arm 2 PRBT and short-term androgen deprivation (STAD): beginning 2 months before the start of PBRT, patients undergo short term androgen deprivation (STAD) for a total of 4-6 months
  • Arm 3 Pelvic lymph node radiotherapy (PLNRT), prostate bed radiotherapy (PBRT), and short term androgen deprivation (STAD): Beginning 2 months before the start of radiotherapy, patients receive STAD treatment as in Arm 2.  Approximately 2 months after beginning STAD, patients undergo PBRT and PLNRT once daily, 5 days a week, for approximately 5 weeks, followed by PBRT only once daily 5 days a week for 2-3 weeks

Disease Status and/or Stage

Prostate Cancer After Radical Prostatectomy

Sponsor

Radiation Therapy Oncology Group, National Cancer Institute

Key Eligibility

  • Men age 18 and older
  • Confirmed diagnosis of prostate cancer, stage N0 or Nx, treated primarily with radical prostatectomy
  • Additional entry criteria discussed when you contact the study team

Principal Investigator

Scott Tagawa, MD

Contact

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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Erica Bersin
Tel: (646) 962-8232
[email protected]

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